The finer the spray particle size, the more uptake and suppression you're likely to get. the official SGML-based PDF version on govinfo.gov, those relying on it for An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement. 1. What is trinexapac-ethyl? Publicly available docket materials are available in the electronic docket at http://www.regulations.gov, or, if only available in hard copy, at the OPP Regulatory Public Docket in Rm. Avoid formation of dust and aerosols. LOAEL = 357 mg/kg/day, based on elevated serum cholesterol values in females, mucoid feces in females and bloody feces in both sexes, and minimal, focal vacuolation of the dorsal medial hippocampus and/or lateral midbrain in both sexes. Registration Review. Lose the iron and calcium. %PDF-1.6 % and services, go to The analysis and recommendations made in this blog post are preliminary and based on research findings from 2013. Health considerations documents in the last year, 20 This final rule does not contain any information collections subject to OMB approval under the Paperwork Reduction Act (PRA), 44 U.S.C. In this Issue, Documents documents in the last year, by the Federal Communications Commission Application of Palisade plus Tilt reduced lodging over Palisade alone at Chickasha. The Agency understands the commenter's concerns and recognizes that some individuals believe that pesticides should be banned completely. rendition of the daily Federal Register on FederalRegister.gov does not Specific information on the studies received and the nature of the adverse effects caused by trinexapac-ethyl as well as the no-observed-adverse-effect-level and the lowest-observed-adverse-effect-level from the toxicity studies can be found at http://www.regulations.gov in the document, Trinexapac-ethyl: Human Health Risk Assessment for the Section 3 Registration Action on Cereal Grains, Sugarcane, and Grasses Grown for Seed p. 48 in docket ID number EPA-HQ-OPP-2010-0524. Export Percentage. PUGVIEW FETCH ERROR: 403 Forbidden National Center for Biotechnology Information 8600 Rockville Pike, Bethesda, MD, 20894 USA Contact Policies FOIA HHS Vulnerability Disclosure National Library of Medicine National Institutes of Health Syngenta Crop Protection, LLC requested these tolerances under the Federal Food, Drug, and Cosmetic Act (FFDCA). Although listed in the index, some information is not publicly available, e.g., Confidential Business Information (CBI) or other information whose disclosure is restricted by statute. EPA has also considered available information concerning the variability of the sensitivities of major identifiable subgroups of consumers, including infants and children. A quantitative and confirmatory method for the analysis of trinexapac (free acid metabolite of trinexapac-ethyl) in wheat is described. The Codex Alimentarius is a joint United Nations Food and Agriculture Organization/World Health Organization food standards program, and it is recognized as an international food safety standards-setting organization in trade agreements to which the United States is a party. Other names: Trinexapac-ethyl, trimethylsilyl ether Permanent link for this species. About the Federal Register This site displays a prototype of a Web 2.0 version of the daily The goal to is to apply trinexapac-ethyl only to the leaf as this is the only route of uptake into the plant. on This action modifies existing tolerances under FFDCA section 408(d) in response to a petition submitted to the Agency. Therefore, apply trinexapac-ethyl in 20 to 30 gallons of water per acre. Therefore, acute aggregate risk is equivalent to the acute dietary risk as discussed in Unit III.C.1.i. The acute dietary exposure was only estimated for females 13 to 49 years old based on an in utero effect (decrease in mean number of fetuses/litter and an increase in post-implantation loss) identified in the rabbit developmental study. [Reserved], [FR Doc. . Use the PDF linked in the document sidebar for the official electronic format. The addition of iron and calcium does not render trinexapac-ethyl inactive, but it may decrease the activity at a given rate. EPA has determined that reliable data show the safety of infants and children would be adequately protected if the FQPA SF Start Printed Page 12744were reduced to 1. C. How can I file an objection or hearing request? Separated from food and feedstuffs. Roanoke, VA 24016. [FR Doc. There are no residual uncertainties in the exposure database. do not apply. Chemical Name: Cyclohexanecarboxylic acid, 4-(cyclopropylhydroxymethylene)-3,5-dioxo-, ethyl ester: Announcements. Until the ACFR grants it official status, the XML It does not represent any guarantee of the properties of the product. Overview Fingerprint Abstract Trinexapac-ethyl (TE) [4- (cyclopropyl--hydroxy-methylene)-3,5- dioxocyclohexanecarboxylic acid ethyl ester] and paclobutrazol (PAC) [ (2RS,3RS)-1- (4-chlorophenyl)-4,4-dimethyl-2- (1H-1,2,4-triazol-1-yl)pentan-3-ol] are routinely esed to suppress clipping production. Containing the same active ingreedient as PRIMO MAXX; PrimeraONE Trinexapac-Ethyl will make your course greener and reduce the number of mowings, saving labor, fuel, and time. documents in the last year, 474 Therefore, for the reasons stated in the preamble, EPA amends 40 CFR chapter I as follows: 1. Establish reliable relationship between buyers and suppliers through our matching services and find new business opportunities through various online exhibitions. Register (ACFR) issues a regulation granting it official legal status. Flurprimidol + trinexapac-ethyl -Edgeless 1.51L, Legacy 1.52 MEC Flurprimidol + paclobutrazol + trinexapac-ethyl -Musketeer 1L Foramsulfuron -Revolver 0.19L The toxicology database for trinexapac-ethyl is largely complete, with the exception of a subchronic neurotoxicity study, which is a new data requirement under 40 CFR part 158 for registration of a pesticide (food and non-food uses OPPTS 870.6200b). Submit a copy of your non-CBI objection or hearing request, identified by docket ID number EPA-HQ-OPP-2010-0524, by one of the following methods: In the Federal Register of August 4, 2010, (75 FR 46925) (FRL-8834-9), EPA issued a notice pursuant to section 408(d)(3) of FFDCA, 21 U.S.C. Syngenta Crop Protection, Inc. requested these tolerances under the Federal Food, Drug, and Cosmetic Act (FFDCA). The telephone number for the Public Reading Room is (202) 566-1744, and the telephone number for the OPP Docket is (703) 305-5805. CAS name: ethyl 4-(cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylate: CAS Reg. These tools are designed to help you understand the official document DER - Trinexapac-ethyl in Water - MRIDs 49282805 & 49282806 (pdf) (238.77 KB) Contact Us to ask a question, provide feedback, or report a problem. In laboratory experiments with annual . if (window != top) documents in the last year, 83 Trinexapac-ethyl is a synthetic plant growth regulator that is derived from cyclohexanecarboxylate. Can you pronounce this word better This additional margin of safety is commonly referred to as the FQPA SF. 1503 & 1507. 272 note). Developmental toxicity was observed in the rat (increased incidence of asymmetrical sternebrae) and rabbit (decreased number of live fetuses/litter and increased post-implantation loss) at the highest dose tested, with no evidence of maternal toxicity observed in either species. Cumulative effects from substances with a common mechanism of toxicity. Full disclosure: Syngenta donated the product for this trial, but the only funding for the research was provided by the Oklahoma Agricultural Experiment Station and the Oklahoma Cooperative Extension Service. The thicker the wheat crop and/or the taller the wheat crop, the more force that winds exert on the root anchorage system and the greater the likelihood of lodging. 2. We included an untreated check and ALL plots, including the check, received 10.5 oz/ac of Quilt Xcel at Feekes GS 10.5 (heading). documents in the last year, 121 For information regarding EPA's efforts to determine which chemicals have a common mechanism of toxicity and to evaluate the cumulative effects of such chemicals, see EPA's Web site at http://www.epa.gov/pesticides/cumulative. The President of the United States communicates information on holidays, commemorations, special observances, trade, and policy through Proclamations. Call a poison control center or doctor for treatment advice If in eyes Hold eye open and rinse slowly and gently with water for 15-20 minutes. menu. 4- (cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylic Acid Ethyl Ester. Chronic exposure. Important Announcement. Conversely, when larger carrier volumes are used, the coarser spray droplets result in reduced foliar coverage. documents in the last year, 87 We rated plots for lodging at harvest using a 1 10 scale with 0 equaling no lodging and 10 equaling complete lodging. In the mouse, there was no evidence of carcinogenicity. Document Drafting Handbook Federal Register. Trinexapac-ethyl is included in Standard category. Trinexapac-ethyl is currently registered for uses that could result in short- and intermediate-term residential exposure, and the Agency has determined that it is appropriate to aggregate chronic exposure through food and water (considered to be a background exposure level) with adult post-application dermal exposure estimates for trinexapac-ethyl. How can I get electronic access to other related information? 4-[cyclopropyl(hydroxy)methylidene]-3,5-dioxocyclohexane-1-carboxylic acid, Growth Retardant Effects Caused By Interfering With Gibberellin Biosynthesis, Plant Growth Regulators (Unclassified Plant Growth Regulators) [1]. EPA has evaluated the available toxicity data and considered its validity, completeness, and reliability as well as the relationship of the results of the studies to human risk. Until the ACFR grants it official status, the XML The OFR/GPO partnership is committed to presenting accurate and reliable documents in the last year, 522 Remove contact lenses, if present, after the first 5 minutes, then Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). Pursuant to the Congressional Review Act (5 U.S.C. LOAEL = 360 mg/kg/day, based on a decrease in mean number of fetuses/litter and an increase in post-implantation loss. Average mass 252.263 Da. All Rights Reserved. to TE has not been widely investigated.In four field experiments, different rates . on 02/28/2023, 267 The following five field observations are strategies that may increase the effectiveness of trinexapac-ethyl when applying it for bermudagrass growth suppression: Use a low carrier volume. X. . Further information regarding EPA standard assumptions and generic inputs for residential exposures may be found at http://www.epa.gov/pesticides/trac/science/trac6a05.pdf. Many Oklahoma wheat farmers battled lodged wheat in 2013 and are looking to plant growth regulators to help reduce lodging in 2014. The Public Inspection page The Codex Alimentarius is a joint U.N. Food and Agriculture Organization/World Health Organization food standards program, and it is recognized as an international food safety standards-setting organization in trade agreements to which the United States is a party. Action: Plant growth . Sign in to access your AXS Fan Account to manage your tickets. The President of the United States issues other types of documents, including but not limited to; memoranda, notices, determinations, letters, messages, and orders. documents in the last year, 20 Global key manufacturers of Trinexapac-ethyl include Syngenta, Nuturf, ADAMA, Nanjing Gaozheng Agricultural Chemical, and Shanghai Agrogreat Industrial, etc. 02/28/2023, 43 Since tolerances and exemptions that are established on the basis of a petition under FFDCA section 408(d), such as the tolerance in this final rule, do not require the issuance of a proposed rule, the requirements of the Regulatory Flexibility Act (RFA) (5 U.S.C. However, to the best of our knowledge, TE has not been used to study the requirement of GAs in onset of germination. Therefore, an additional 10x database UF was not retained for lack of inhalation toxicity data and these data are not being required. Use the PDF linked in the document sidebar for the official electronic format. Dietary exposure from food and feed uses. The quality of Trinexapac-ethyl 95266-40-3 will be secured by ECHEMI. name for 4-(cyclopropyl--hydroxymethylene)-3,5-dioxo-cyclohexanecarboxylic acid ethyl ester . Palisade did not affect lodging at Perkins. Trinexapac-ethyl (Ref: CGA 163935) (Also known as: trinexapac; cimectacarb-ethyl; cimectacarb) The following alerts are based on the data in the tables below. Our results are consistent with other wheat plant growth regulator research, which has reported similar variation in response among sites and years. Developmental rabbit study. Thus, the Agency estimates risk in terms of the probability of an occurrence of the adverse effect expected in a lifetime. It is interesting to note that the Palisade treatment increased grain yield at Perkins even though the plots lodged at comparable levels as the non treated check. Pesticide manufacturing (NAICS code 32532). Research has shown that increasing the soil water content from 17 to 26% reduced the force required for anchorage failure by 33%, and as little as 0.25 inches of water plus 11 mph winds were enough to cause lodging. For complete information about, and access to, our official publications The objective of this work was to evaluate the effect of trinexapac-ethyl and nitrogen doses on the agronomic performance and grain yield of three wheat cultivars. These can be useful This feature is not available for this document. Trinexapac-ethyl CAS 95266-40-3 WIKI information includes physical and chemical properties, USES, security data, NMR spectroscopy, computational chemical data and more. Residues were extracted from wheat with acetonitrile in aqueous phosphate buffer (pH 7) overnight. 1029 0 obj <>/Filter/FlateDecode/ID[<9B9F72845FCBC54B95A1BA019DA6AE45>]/Index[1016 20]/Info 1015 0 R/Length 73/Prev 68852/Root 1017 0 R/Size 1036/Type/XRef/W[1 2 1]>>stream Trinexapac-ethyl can be used in many areas that can be frequented by the general population including residential areas (e.g., home lawns, recreational turf). documents in the last year, 822 Many applications of trinexapac-ethyl are mixed with an iron-containing product to mask bronzing that may occur. Personal protection: P2 filter respirator for harmful particles. 321(q), 346a and 371. ii. Neither comment was accompanied by any substantiation nor data supporting a conclusion that the tolerances being established in this action do not meet the FFDCA safety standard. electronic version on GPOs govinfo.gov. There is the potential for incidental oral exposure; however, since there is no toxicological endpoint of concern for that route, a quantitative assessment was not conducted. LOC for MOE = 100. TermsPrivacy NoticeOSU Agriculture Division 2022 Oklahoma State University. 801 et seq., generally provides that before a rule may take effect, the agency promulgating the rule must submit a rule report to each House of the Congress and to the Comptroller General of the United States. Since tolerances and exemptions that are established on the basis of a petition under section 408(d) of FFDCA, such as the tolerance in this final rule, do not require the issuance of a proposed rule, the requirements of the Regulatory Flexibility Act (RFA) (5 U.S.C. 346a(d)(3), announcing the filing of two pesticide petitions (PP 0F7719 and 0F7720) by Syngenta Crop Protection, Inc., P.O. on Use non-sparking tools. 1. documents in the last year, by the Federal Highway Administration Trinexapac-ethyl is a plant growth regulator that inhibits the biosynthesis of gibberellin. documents in the last year, 36 Therefore, 40 CFR chapter I is amended as follows: 1. on NARA's archives.gov. III. Information not marked confidential pursuant to 40 CFR part 2 may be disclosed publicly by EPA without prior notice. From non-dietary exposure. that agencies use to create their documents. In the event of a Toxic or Transport Emergency in the UK please telephone 01484538444 at any time. You may access a frequently updated electronic version of EPA's tolerance regulations at 40 CFR part 180 through the Government Printing Office's e-CFR site at http://ecfr.gpoaccess.gov/cgi/t/text/text-idx?&c=ecfr&tpl=/ecfrbrowse/Title40/40tab_02.tpl. The suppliers of 39 Trinexapac-ethyl on the search result are been verified by the accurate information of each one. documents in the last year, by the Centers for Medicare & Medicaid Services Clethodim. P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal. of the issuing agency. Mohammad Hossein Sheikh Mohammadi, et al. Find your Trinexapac-ethyl order with 70000+ buyers on ECHEMI. To ensure proper receipt by EPA, you must identify docket ID number EPA-HQ-OPP-2010-0524 in the subject line on the first page of your submission. 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Ether Permanent link for this document WIKI information includes physical and chemical properties, USES, security,... Uk please telephone 01484538444 at any time How can I file an or. Risk in terms of the probability of an occurrence of the probability of occurrence. Wheat plant growth regulator research, which has reported similar variation in response among sites and years sensitivities. Loael = 360 mg/kg/day, based on a decrease in mean number fetuses/litter. Not render trinexapac-ethyl inactive, but it may decrease the activity at a given rate can you pronounce this better. Acid, 4- ( cyclopropyl -- hydroxymethylene ) -3,5-dioxo-cyclohexanecarboxylic acid ethyl ester: Announcements of! To 30 gallons of water per acre trimethylsilyl ether Permanent link for this document regulator that inhibits the of. Name for 4- ( cyclopropylhydroxymethylene ) -3,5-dioxo-, ethyl ester: Announcements the last year by. 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