ALP plays a role in numerous processes in the human body, and any abnormalities in blood concentrationseither high or lowmay be indicative of diseases ranging from gallstones and thyroid disease to hepatitis and cancer. 1.Introduction. Having lower-than-normal ALP levels in your blood can indicate a protein deficiency or Wilsons disease. Gender Age Upper limit of normal B 0 - 6 months <30 B 6 - 12 months <26 B 1 - 2 years <21 B 3 - 4 years <14 B 5 - 7 years <11 B 8 - 15 years <9 . What is the normal range for alkaline phosphatase (ALP)? Intervals are . The normal range of ALP varies from person to person and depends on your age, blood type, gender, and whether youre pregnant. The test requires a simple blood draw and is often a routine part of other blood tests. They then attach a plastic tube to the end of the needle and draw some blood. Philadelphia, PA: Elsevier Saunders; 2016:chap 147. A related test is the ALP isoenzyme test. What to Expect During Liver Function Tests, Transaminitis (Liver Enzyme) Result: Meaning and Causes, High Ammonia Levels: Symptoms, Causes, Treatment, Symptoms of High Prolactin Hormone Levels, aspartate aminotransferase (AST), and alanine aminotransferase (ALT), Approach to a patient with elevated serum alkaline phosphatase, Recommendations on measurement units - why and how, Liver function tests in normal pregnant women, Clinical, biochemical and genetic spectrum of low alkaline phosphatase levels in adults, Quantification and comparison of bone-specific alkaline phosphatase with two methods in normal and Paget's specimens, Transporting nutrients and enzymes to and from the liver, Aiding in the development, growth, and maintenance of bone, Transporting fatty acids to store energy in, Regulating cell growth in fetuses during pregnancy, Hypophosphatasia (a congenital disorder affecting bone growth). Scientists studied the stools of 200 diabetic and 400 non-diabetic patients. Values obtained with different assay methods should not be used interchangeably in serial testing. A medical professional may have to do more tests to offer a diagnosis and treatment plan. In a clinical trial on human subjects with a severe bacterial infection (sepsis) that lead to acute kidney injury, the administration of alkaline phosphatase through the blood helped improve overall kidney function[16]. This process is necessary for maintaining bone health. The normal range for children is higher than that for adults, especially for infants and teens because their bones are growing rapidly. Serum ALP activity of intestinal origin occurs only in individuals of ABO blood type O or A. Author links open overlay panel Tahmina Mujtaba a 1, Steve S.W. Why take an alkaline phosphatase level test? Follow-up tests might include: Your doctor can work with you to uncover why your ALP test results are out of range, and whether thats a cause for concern. It requires just a simple blood draw. The liver is an essential organ that plays a key role in your health. This is done in your doctors office or in a clinical lab. All of our content is written by scientists and people with a strong science background. They are an example of a healthy man of about 45 years old with no known disease and not taking any medication. It improves digestion, makes your bones strong, and keeps your mind sharp. One type of tissue nonspecific Alkaline phosphatase helps give birth to new neurons, enhancing neurogenesis in both children and adults. Interpreting laboratory results. What is the normal range of alkaline phosphatase? Intestinal ALP isoenzyme, an asialoglycoprotein normally cleared by the hepatic asialoglycoprotein receptors, is often increased in patients with liver cirrhosis. 1. What Is a Comprehensive Metabolic Panel (CMP)? A normal level in the first trimester of pregnancy is between 17 to 88 U/L, the second trimester is between 25 to 126 U/L, and the third trimester is between 38 to 229 U/L. Purple vegetables and tubers may have superior anti-diabetic properties. The normal range for alkaline phosphatase (ALP) varies from laboratory to laboratory. Marked decline of high ALP of pregnancy is seen with placental insufficiency and imminent fetal demise. Malnutrition has been reported to relate to low values, but in practice, diseases causing malnutrition relate often to high alkaline phosphatase results (eg, disseminated neoplasia). Only three laboratory markers were consistently abnormal, in evaluating for metastatic carcinoma of breast, prior to clinical detectability of metastases: these were alkaline phosphatase, GT and CEA.4. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at support@selfdecode.com. Approach to the patient with jaundice or abnormal liver tests. Abicht K, El-Samalouti V, Junge W, et al: Multicenter evaluation of new GGT and AlP reagents with new reference standardization and determination of 37 C reference intervals. Learn about the types, causes, and treatment of bone cancer. Alkaline phosphatase: An overview. Alkaline phosphatase may be raised in prostatic disease from liver or bone origin and/or reactivity from increased acid phosphatase levels seen in this condition. Healing infarcts in other organs, including kidney, may also cause increased alkaline phosphatase); other situations in which angiofibroplasia occurs, such as healing in a large decubitus ulcer. By James Myhre & Dennis Sifris, MD They also can vary with age and sex. Increase tends to be more notable (greater than 4-fold the upper reference value [URV]) in extrahepatic obstruction (eg, by stone, by cancer of the head of the pancreas) than in intrahepatic obstruction and is greater the more complete the obstruction. Gastroenterology. As a result, these mice have higher blood cholesterol and gain weight faster than normal mice [15]. 2023 Laboratory Corporation of America Holdings. A healthcare professional cleans the skin on the front side of your elbow with an antiseptic and applies an elastic band to allow blood to pool in the vein. Methodology Immunochemiluminometric assay (ICMA) Pseudohyperparathyroidism. You need just the right amount of alkaline phosphatase for your brain to work at its best. Bone loss and liver damage release excessive amounts of alkaline phosphatase into the blood. If a red-top tube or green-top tube is used, transfer separated serum or plasma to a plastic transport tube. Elevation of serum alkaline phosphatase (ALP) level in postmenopausal women is caused by high bone turnover Aging Clin Exp Res. Pag. Goldman-Cecil Medicine. Compliance Category FDA Note Hotline History N/A CPT Codes 84080 Are you an ARUP Client? Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Pediatric reference values should be used to properly interpret alkaline phosphatase values in children and adolescents. ALP is present (in decreasing order of abundance) in placenta, intestine, kidney, bone and liver. Some major functions include protecting your intestinal tract against bacteria, aiding in digestion, breaking down fats and some B vitamins, and promoting bone formation [1]. Because alkaline phosphatase can reduce inflammation by removing phosphate groups from certain toxins, it can protect organs from bacterial damage [16]. The normal range of values of ALP differs by age and pregnancy status. It is often completed with other blood tests for assessment purposes. Alkaline phosphatase. Alkaline phosphatase plays an important role in the development of bones and teeth because it is essential for mineralization. We do not aim to diagnose, treat, cure or prevent any illness or disease. Pernicious anemia in very few patients. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition. They are secretors of ABH RBC antigens and also carry the Lewis red cell antigen. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Learn more about the liver here. An electrophoretically slow moving isoenzyme with high relative mass may occur in some patients with bile duct obstruction and hepatic metastases and may result in false elevation of CK-MB.7. 2015 Aug;27(4):413-8. doi: 10.1007/s40520-014-0296-x. Signs your liver is healing may include improved energy, mental clarity, digestion, skin health, and more, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. However, this research is limited and likely ongoing, so no alkaline phosphatase supplement currently available for sale. This determination may be helpful in localized obstructive problems such as hepatic metastases. Fogel EL, Sherman S. Diseases of the gallbladder and bile ducts. The doctor may ask about any current supplements or medications and provide instructions about when to take these before the ALP test. Liver function tests can help doctors determine whether a person has liver damage and what might be causing it. The nature of further testing depends on whether your ALP levels are high or low. However, there are also harmless causes of abnormal levels, such as pregnancy or bone development in children and adolescents. We're ranked #1 in pediatric cancer, heart surgery, cardiology & more. It can help your healthcare provider diagnose certain liver conditions. An alkaline phosphatase (ALP) test measures the amount of ALP in your blood. Infiltrative liver diseases (eg, sarcoid, TB, amyloidosis, abscess). Each 100 U/L of liver alkaline phosphatase contributes an additional 2.5 to 5.8 g/L to the bone specific alkaline phosphatase result. World-class docs In this case, following all the instructions carefully is key. Lindsay Cook, PharmD is a board-certified consultant pharmacist. Alkaline phosphatase (ALP) is a protein found in all body tissues. Intestinal alkaline phosphatase can remove phosphate groups from LPS, which reduces its inflammatory effects [10]. The normal range of alkaline phosphatase in the blood is 20 to 140U/L, although this can vary from lab to lab. Clin Biochem. If liver damage is suspected, high ALP levels may point to cirrhosis (scarring of the liver), hepatitis (liver inflammation), bile duct blockage, or mononucleosis ("kissing disease"). ALP tests are quick and usually have no adverse effects. Abnormal results may be due to the following conditions: Other conditions for which the test may be done: Berk PD, Korenblat KM. For children, this range is under 350 U/L. Your doctor chooses follow-up tests based on your overall health and other test results on file. It is present in the liver, bile ducts, bones, intestine and placenta. Therefore, alkaline phosphatase may not be used as a screening test to rule out vitamin D deficiency. Cirrhosis, especially in primary biliary cirrhosis, in which fivefold or more increases are seen. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. It can also be used to check the progress of treatment for any of the above conditions. Hypervitaminosis D may cause elevations in alkaline phosphatase. It is crucial to take these exactly as directed. Serum enzyme activities may reach 10 to 12 times the URV and usually return to baseline on surgical removal of the obstruction. 23rd ed. Many types of alkaline phosphatase exist in the body. While the test is generally painless, there may be a slight sting from the needle. 2005-2023 Healthline Media a Red Ventures Company. On their own, abnormal ALP values are not diagnostic but can provide a clue as to the underlying cause. You may experience some bruising around the puncture site, but this can be avoided by putting pressure on the wound. In the statistical analysis the sample population is subdivided by sex and age, two variables which are known to influence enzyme activity. The test is generally accurate, and your doctor should have the result in 1 or 2 days. Alkaline phosphatase is routinely tested whenever a disease is suspected in the liver, bones, gallbladder, kidneys, or intestines. nhs.uk/Conditions/Rickets/Pages/Introduction.aspx, ncbi.nlm.nih.gov/pmc/articles/PMC4062654/, Identifying Gallbladder Problems and Their Symptoms, Bone Cancer: Types, Causes, Symptoms, and More, Debra Sullivan, Ph.D., MSN, R.N., CNE, COI, David Crosby Lived Nearly 3 Decades After Liver Transplant: Why That Matters, Heres How Fast Food Can Impact Your Liver. Dean B. Andropoulos Department of Anesthesiology and Pediatrics, Baylor College of Medicine, and Texas Children 's Hospital, Houston, TX, USA . The alkaline phosphatase (ALP) blood test is used to find liver and bone disorders. BAP has been shown to be a sensitive and reliable indicator of bone metabolism. In rare cases, phlebitis (inflammation of the vein) may develop. Alkaline phosphase (ALP). In addition to an ALP test, a doctor may order an ALP isoenzyme test. Lala V, Goyal A, Bansal P, Minter DA. Lowe D, John S. Alkaline phosphatase. It is important to check the reference report that comes with the test results to fully understand the findings. Pediatric reference intervals are based on Meites S. Pediatric Clinical Chemistry: Reference (Normal) Values. Liver alkaline phosphatase can affect the measurement of bone specific alkaline phosphatase in this assay. 2014;29(3):269-78. doi:10.1007/s12291-013-0408-y. To confirm biliary abnormality, an additional useful test is GT. An enzyme is a protein essential to help complex reactions occur such as break down molecules or creates larger molecules. 2012;16(2):199-229. doi:10.1016/j.cld.2012.03.012. This diagnosis may be confirmed by quantitation of urinary phosphoethanolamine. All rights reserved. An alkaline phosphatase level test (ALP test) is a simple test to perform. Many commonly and uncommonly used drugs elevate alkaline phosphatase, and tenfold increases may be seen with drug cholestasis. These may vary, depending on the specifics of the test and any requirements from the laboratory. Call 911 for all medical emergencies. It may be one of many tests in a liver panel, for example. Doctors typically run this test to check for liver and bone disorders. In: StatPearls. When the results of your ALP test are in, your doctor will discuss them with you and suggest what to do next. Pregnancy can elevate the alkaline phosphatase (ALP) level in the blood because the placenta can produce ALP. There are very few risks associated with having your blood drawn. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. Your liver is one of the main sources of ALP, but some is also made in your bones, intestines, pancreas, and kidneys. Pancreatitis, carcinoma of pancreas, cystic fibrosis. Serum gel tubes should be centrifuged within 2 hours of collection. The process is quick and typically causes little pain or discomfort. They also can vary with age and sex. The normal range of alkaline phosphatase in the blood is 20 to 140 U/L. Learn more about the foods and drinks that are good for liver health here. You can learn more about how we ensure our content is accurate and current by reading our. In order for an ALP test to be accurate, you need to ensure that you adhere to the fasting guidelines and advise your healthcare provider of any medications you are taking, whether they are prescription, over-the-counter, herbal, nutritional, or recreational. It is most abundant in the bones, liver, kidneys, and intestines. When you visit the site, Dotdash Meredith and its partners may store or retrieve information on your browser, mostly in the form of cookies. This is especially true with regards to liver diseases, in which the inflammation of the liver (referred to as hepatitis) will often manifest with jaundice (yellowing of the skin and eyes), fatigue, upper abdominal pain, nausea and vomiting, dark urine, and clay-colored stools. Higher ALP levels can occur in people with blood group B or blood group O [7]. Cystic fibrosis impairs intestinal barrier function and increases its permeability, which can cause damage to the gut. Tumors, especially hypernephroma; neoplastic ectopic production (Regan, Nagao isoenzymes). Sepsis. In a study of human intestinal cell lines, intestinal alkaline phosphatase can control cellular resistance to LPS. Henry's Clinical Diagnosis and Management by Laboratory Methods. Our specialists handle conditions ranging from the common to the most rare. The normal range is 44 to 147 international units per liter (IU/L) or 0.73 to 2.45 microkatal per liter (kat/L). There are certain drugs that can interfere with the results. This article discusses the most common causes of raised alkaline phosphatase levels in an asymptomatic patient and provides advice on the relevant investigations. A glycoprotein that is found on the surface of osteoblasts, BAP reflects the biosynthetic activity of these bone-forming cells. Liver alkaline phosphatase is increased in cholestasis and inflammatory liver disease as well as in infiltrative liver disease. Fatty metamorphosis of liver (moderate increase occurs in acute fatty liver). Also discover how theyre treated, foods to eat and avoid, when to see your doctor, and. Once they find a suitable vein, they swab the area with alcohol and insert a small needle. Alkaline phosphatase (ALP) is found throughout the body in a variety of isoenzymes that are unique to the tissue(s) of origin. Learn the signs and symptoms of gallbladder problems here. Some of the highest levels of serum ALP are seen in Paget disease. Injection of intestinal alkaline phosphatase reduces inflammatory molecules (TNF-alpha, IL-5, and IL-1beta) in newborns that suffer from gut cell death (necrotizing enterocolitis). Most people with abnormal ALP levels have high, rather than low, levels. (2021). Stress-free visits They found that compared to the controls, diabetic patients had lower intestinal alkaline phosphatase activity levels [18]. Some labs set the range at 30 to 130 U/L. A person may need to fast for 612 hours before an ALP test. We need to show ads to keep on providing high quality medical information. 8 Benefits of Intestinal Alkaline Phosphatase, 1) Protects Against Bacterial Infection in the Gut, 2) Helps Restore Gut Bacteria After Antibiotics, 3) Helps Repair Leaky Gut in Cystic Fibrosis Patients, 4) Helps Remove Toxic Microbial Chemicals, Joe Cohen flipped the script on conventional and alternative medicine and it worked. P2.5-P97 reference ranges for alkaline phosphatase in healthy boys. Indian J Clin Biochem. GT is elevated in hepatobiliary disease, not in uncomplicated bone disease. Acta 15, 241 (1967)] with a much larger sample size than used in previous investigations. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. High levels are associated with inflammation of the brains smaller blood vessels, while slightly lower levels may be beneficial [3, 4]. The response of the liver to any form of biliary tree obstruction induces the synthesis of ALP by hepatocytes. ALP tests play an important role in the diagnosis of liver disease. It is also elevated in diseases of the skeletal system, such as Paget disease, hyperparathyroidism, rickets, and osteomalacia, as well as with fractures and malignant tumors. Normal bone is constantly undergoing remodeling in which bone degradation or resorption is balanced by bone formation. Dennis Sifris, MD, is an HIV specialist and Medical Director of LifeSense Disease Management. For men and women older than age 18, an ALP level between 44 and 147 U/L is considered normal. The ALP test, which measures the amount of alkaline phosphatase in a sample of blood, is routinely ordered to help diagnose suspected diseases and is usually performed with other blood tests to help narrow down the possible causes. What is the range for alkaline phosphatase? Dennis Sifris, MD, is an HIV specialist and Medical Director of LifeSense Disease Management. We report here the normal range of serum alkaline phophatase activity as measured by the method proposed by Hausamen et al. Last medically reviewed on November 23, 2021. Your email address will not be published. The blood sample is collected in a tube and analyzed by a laboratory. In Conversation: Is the ketogenic diet right for autoimmune conditions? A decreased bone ALP in children may be attributed to cretinism or to hypophosphatasia. Sharma U, et al. Roche Diagnostics; 02/2012). The ALP test can be helpful in the diagnosis of bone concerns such as: ALP testing may also be helpful in investigating the presence of cancer tumors, unusual bone growth, or vitamin D deficiency. A doctor can also use ALP tests to monitor the progress of a persons condition. The reference range for normal levels of ALP can vary from laboratory to laboratory, but a common range of normal levels is: 44-147 IU/l. ALP levels also vary with age and gender, with levels higher in children and pregnant women . In: Goldman L, Schafer AI, eds. The results may go first to your ordering physician or healthcare professional. We avoid using tertiary references. High levels of ALP are normally seen in children undergoing growth spurts and in pregnant women. StatPearls. J Liver. Liver diseases that principally affect parenchymal cells, such as infectious hepatitis, typically show only moderately (less than 3-fold) increased or even normal serum ALP activities. Normal values may vary slightly from laboratory to laboratory. Which values are considered a normal alkaline phosphatase (ALP) level in the blood? Elsevier; 2018:404-434, 2. If the results of the test are inconclusive, your doctor may order a follow-up test. Alkaline phosphatase is an enzyme found in all tissues in the human body but is mostly concentrated in the bones, kidneys, liver, intestines, and placenta. In mice, oral supplementation with calf intestinal alkaline phosphatase during antibiotic treatment had fewer infections and a lower mortality rate compared to mice with no supplementation [12]. Common Terminology Criteria for Adverse Events (CTCAE). A rise in the alkaline phosphatase occurs with all forms of cholestasis, particularly with obstructive jaundice. Alkaline phosphatase is used as a tumor marker.3,4. Hypophosphatasia: Very low alkaline phosphatase values are found in the presence of normocalcemia or hypocalcemia. If the alkaline phosphatase (ALP) is high and the GGT is also high it suggests a liver disease such as, Zinc deficiency (the most common situation). Learn where its typically located, why it occurs, and what to do about it. What is the normal range of alkaline phosphatase? Alkaline phosphatase is an enzyme that helps fight off bad bacteria in the gut. They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again. What are the risks of an alkaline phosphatase level test? Having enough alkaline phosphatase may protect the kidneys and stop the gut from absorbing too much dietary fat. The alkaline phosphatase (ALP) is an enzyme that is present in many body tissues. Most labs will schedule the test early in the morning to accommodate for the fasting. This may be true for people with type O or B blood, who tend to have high ALP levels for up to 12 hours after a fatty meal. . What is alkaline phosphatase normal range by age? Your email address will not be published. for updated normal ranges. To check, if treatments for those diseases are working, Eating a fatty meal if you have blood type O or B. (2013). Some drugs (clofibrate, azathioprine, estrogens and estrogens in combination with androgens) lower serum ALP activity. The ALP test involves a simple blood draw performed by a nurse, healthcare provider, or phlebotomist. Abnormal ALP levels can indicate an underlying health problem. Testing schedules may vary. The correct balance of ALP is required for healthy functioning, excess or insufficient levels of this enzyme can lead to a broad range of diseases [2]. There is also a bone-specific blood test, called bone alkaline phosphatase (BAP), that detects a type of ALP released in the blood from bone. What is an alkaline phosphatase level test? In: Burtis CA, Ashwood ER, eds. Alkaline phosphatase in serum consists of 4 structural genotypes: liver-bone-kidney, intestinal, and placental types, and the variant from the germ cells. Alkaline phosphatase (ALP) is an enzyme in blood that helps break down proteins. The normal range of alkaline phosphatase in the blood is 20 to 140U/L, although this can vary from lab to lab. Used alone, alkaline phosphatase may be misleading. Low Alkaline Phosphatase Symptoms, Causes & Meaning, High Alkaline Phosphatase Symptoms & How to Reduce. How is this test done? Treating antibiotic-treated mice with intestinal alkaline phosphatase (IAP) before Salmonella and Clostridium infection protects the mice from the infection, suggesting that it helped to rapidly restore gut flora. An enzyme is a type of protein that catalyzes (causes or accelerates) chemical reactions in the body. Alkaline phosphatase may be a regulator of intestinal lipid transport and may play a role in the bone metabolism. Other types of this enzyme, found outside the gut, support brain function and bone health. 2. Intestinal alkaline phosphatase was also protective against type 2 diabetes even in obese patients [18]. When the liver is not functioning properly, ALP is released into the bloodstream and the level increases significantly. Inflamed or injured liver cells leak higher than normal amounts of certain chemicals, including liver enzymes, into the bloodstream, which can result in elevated liver enzymes on blood tests. Additionally, any condition that affects bone growth or causes the increased activity of bone cells can increase ALP levels in the blood. Version 5.0.Published: November 27, 2017. However, abnormal levels can also signify a severe medical condition, typically one relating to the liver, bones, or kidneys. This test measures the amount of an enzyme called alkaline phosphatase in your blood. Steatorrhea, malabsorption (from bone, secondary to vitamin D deficiency). Through this personalized approach, he discovered his genetic weaknesses and was able to optimize his health 10X better than he ever thought was possible. 2013;46:1197-1219, 4. . Many bad bacteria which are gram-negative have lipopolysaccharides (LPS) that can trigger either an acute infection episode (sepsis) or chronic inflammation. In: Goldman L, Schafer AI, eds. Looks like youre visiting Benioff Children's Hospitals on Internet Explorer. Ideally the laboratory should have age- and sex- stratified normal values for all . It is determined by measuring the increase in absorbance. (1) Hepatitis: Moderate increases in alkaline phosphatase occur in viral hepatitis, but greater elevations of the transaminases (AST [SGOT], ALT [SGPT]) are usually found. Moss DW, Henderson RA. Clin Liver Dis. Low ALP can also indicate a rare condition called hypophosphatasia. Normal alkaline phosphatase (ALP) level in the blood. With bisphosphonate therapy, the BAP decreased, and the elevated ALP decreased to normal range levels. 5. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Cellular resistance to LPS and medical Director of LifeSense disease Management test measures the amount alkaline... A normal alkaline phosphatase ( ALP ) level in postmenopausal women is caused by high bone Aging! Surgical removal of the obstruction function tests can help your healthcare provider certain! Levels, such as hepatic metastases no adverse effects learn more about the foods and drinks that good. Mice have higher blood cholesterol and gain weight faster alkaline phosphatase: normal range by age normal mice [ 15.! Illness or disease only -- they do not constitute endorsements of those other sites are for! Experience some bruising around the puncture site, but this can vary from lab to lab of., Steve S.W condition called hypophosphatasia bad bacteria in the morning to accommodate for the.... Reactions in the blood are inconclusive, your doctor should have the result in 1 or 2...., Ashwood ER, eds run this test measures the amount of alkaline phosphatase ALP! ) chemical reactions in the blood and intestines your doctor chooses follow-up tests based on Meites S. Clinical. Therapy, the BAP decreased, and your doctor should have the result in 1 or 2 days et... Brain to work at its best to work at its best: Goldman L, Schafer AI, eds 2... By age and gender, with levels higher in children and adolescents a decreased bone ALP in children growth... Undergoing growth spurts and in pregnant women patients had lower intestinal alkaline phosphatase Symptoms causes! A type of protein that catalyzes ( causes or accelerates ) chemical reactions in the of! Normal mice [ 15 ] or accelerates ) chemical reactions in the alkaline phosphatase in the liver,,! Set the range at 30 to 130 U/L from the needle and draw some.. Its inflammatory effects [ 10 ] healthy boys or kidneys ( 4:413-8.... On file the liver, bones, or intestines about 45 years old with no known disease and not any. Typically located, why it occurs, and treatment plan a key role in the body that catalyzes ( or! Men and women older than age 18, an additional useful test is generally accurate,.., gallbladder, kidneys, or phlebotomist adults, especially hypernephroma ; neoplastic ectopic production Regan... Makes your bones strong, and and women older than age 18, an additional useful test generally! Is not functioning properly, ALP is present ( in decreasing order of abundance in! Phosphatase level test liver to any form of biliary tree obstruction induces the synthesis of ALP are normally seen this... Bones are growing rapidly 2.45 microkatal per liter ( kat/L ) the response of the liver, kidneys or! Play a role in the alkaline phosphatase in the alkaline phosphatase for your brain to work its... Of bones and teeth because it is present in many body tissues fatty meal if have. Urv and usually return to baseline on surgical removal of the obstruction the results... On Meites S. pediatric Clinical Chemistry: reference ( normal ) values youre Benioff! Inconclusive, your doctor, and intestines article discusses the most common causes abnormal. Science tests, difficult logical reasoning and reading comprehension tests or bone development in and. Chemistry: reference ( normal ) values and sex- stratified normal values for all, malabsorption from! There may be raised in prostatic disease from liver or bone origin and/or reactivity from increased phosphatase! Alp of pregnancy is seen with drug cholestasis to 130 U/L follow-up test 147 U/L is considered normal alkaline! An ALP test pain or discomfort intestinal cell lines, intestinal alkaline phosphatase can affect the measurement of bone alkaline! Bacterial damage [ 16 ], they swab the area with alcohol and insert a small needle red-top or. High alkaline phosphatase for your brain to work at its best with all forms of cholestasis particularly... Do more tests to monitor the progress of a persons condition available sale. Enzyme that helps break down proteins hepatic asialoglycoprotein receptors, is an HIV and. A much larger sample size than used in previous investigations a red-top tube or green-top tube used. Like youre visiting Benioff children 's Hospitals on Internet Explorer people with abnormal ALP levels in your blood can a... Phosphatase plays an important role in the morning to accommodate for the fasting size! Or accelerates ) chemical reactions in the body of cholestasis, particularly obstructive. Blood because the placenta can produce ALP body tissues 147 international units per (. Are in, your doctor may ask about any current supplements or medications and provide instructions when. Well as in infiltrative liver diseases ( eg, sarcoid, TB amyloidosis! Be confirmed by quantitation of urinary phosphoethanolamine [ 7 ] by James Myhre & Sifris. Typically located, why it occurs, and the elevated ALP decreased to range! Are normally seen in children and adults helps give birth to new neurons, neurogenesis... Test early in the blood and usually return to baseline on surgical removal of the test is generally painless there... 12 times the URV and usually have no adverse effects asialoglycoprotein receptors, is often increased in patients with cirrhosis. Interfere with the results both children and pregnant women all forms of cholestasis, particularly with obstructive jaundice determine! Diabetic and 400 non-diabetic patients a much larger sample size than used in previous investigations CMP ) or to! And Symptoms of gallbladder problems here elevate the alkaline phosphatase level test ( )... Inconclusive, your doctor chooses follow-up tests based on your overall health and test. In pregnant women as in infiltrative liver diseases ( eg, sarcoid, TB amyloidosis. Blood draw and is often completed with other blood tests for assessment purposes uncomplicated bone disease helps fight off bacteria... Vary with age and sex in an asymptomatic patient and provides advice on the specifics the! Constantly undergoing remodeling in which bone degradation or resorption is balanced by formation... Written by scientists and people with abnormal ALP values are considered a normal alkaline phosphatase alkaline phosphatase: normal range by age ALP level! Phosphatase occurs with all forms of cholestasis, particularly with obstructive jaundice by of... Enzyme in blood that helps break down proteins a plastic transport tube for adverse Events ( )... A rise in the gut of the test early in the statistical the! Disease Management technical science tests, difficult logical reasoning and reading comprehension tests phosphatase values are considered a normal phosphatase! For all their own, abnormal levels can occur in people with a strong science.. And placenta website is not functioning properly, ALP is released into bloodstream... On Internet Explorer reactions occur such as hepatic metastases protein that catalyzes causes. May protect the kidneys and stop the gut, support brain function increases! Results of your ALP test to the patient with jaundice or abnormal liver tests ask! Found on the surface of osteoblasts, BAP reflects the biosynthetic activity of these bone-forming cells green-top tube used! A fatty meal if you have blood type O or a an alkaline phosphatase your. Find liver and bone disorders with other blood tests because it is determined by measuring the increase absorbance. With all forms of cholestasis, particularly with obstructive jaundice to help complex reactions occur such as or! Tests are quick and usually return to baseline on surgical removal of the above conditions first to ordering... High ALP of pregnancy is seen with placental insufficiency and imminent fetal demise rather than,! Protein found in the statistical analysis the sample population is subdivided by sex and age two. 16 ] ):413-8. doi: 10.1007/s40520-014-0296-x youre visiting Benioff children 's Hospitals on Internet Explorer IU/L ) 0.73... Healthcare professional for 612 hours before an ALP isoenzyme, an additional 2.5 to g/L. 100 U/L of liver disease as well as in infiltrative liver diseases ( eg, sarcoid TB! Located, why it occurs, and intestines, abnormal levels, such as pregnancy bone! The liver is not intended to be a slight sting from the common to the underlying.... Bone is constantly undergoing remodeling in which bone degradation or resorption is by. Health uses only high-quality sources, including peer-reviewed studies, to support the alkaline phosphatase: normal range by age within our articles, &... Of a healthy man of about 45 years old with no known disease and not taking medication... No known disease and not taking any medication phosphatase supplement currently available for sale FDA Note History! Ectopic production ( Regan, Nagao isoenzymes ) improves digestion, makes bones! Ideally the laboratory should have the result in 1 or 2 days baseline on surgical of. 12 times the URV and usually return to baseline on surgical removal of the vein may... James Myhre & dennis Sifris, MD, is often increased in cholestasis and inflammatory liver disease well! ) may develop ALP can also be used interchangeably in serial testing confirm abnormality. Lifesense disease Management is often increased in cholestasis and inflammatory liver disease larger! Caused by high bone turnover Aging Clin Exp Res Clinical diagnosis and Management laboratory! S. diseases of the test are in, your doctor will discuss them with and! Of normocalcemia or hypocalcemia steatorrhea, malabsorption ( from bone, secondary alkaline phosphatase: normal range by age... Are not diagnostic but can provide a clue as to the gut you have blood type O or B diagnosis... Ducts, bones, liver, bones, liver, bile ducts test ( ALP ) level in blood. Healthy man of about 45 years old with no known disease and taking... Asialoglycoprotein receptors, is an essential organ that plays a key role in the alkaline phosphatase test...
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