Red chests), Can be used in a shop to duplicate pickups which have not yet been purchased, and take the duplicate pickup for free, UNLOCK: Unlock this item by defeating Greedier Mode with Isaac, When used, Void will consume any pedestal items in the current room, If an active item is consumed, its effect will be added to Void's effect when used, allowing you to consume multiple items and combine their effects, If a passive item is consumed, you gain a small stat upgrade to a random stat, Possible stat changes include: +1.0 flat damage, +0.5 tears, +0.2 speed, +0.2 shot speed, +0.5 range, +1.0 luck, Void does not work on devil deal or shop items unless they have been bought first, Using Void to absorb items in Boss Rush or Challenge Rooms counts as taking the items and will cause the encounter to start, Using Void on one time use items such as Mama Mega or Diplopia will cause their effect to instantly trigger and will not give you further uses through activating Void again, UNLOCK: Unlock this item by beating Delirium in The Void floor with Apollyon, Upon use, this item freezes all enemies in the room until you press the fire button again or 30 seconds passes (whichever happens first), Unlike other active items, bosses are not immune to this effect, Touching a frozen enemy will still hurt you, This item doesn not affect troll bombs - they will still explode, Upon use, the Smelter will destroy your currently held trinket and give you the effect permanently, allowing you to stack up lots of different trinket effects, Holding the Smelter increases the chance for a trinket to drop. * item room, treasure room, item room pool, money is power, dollar, red, grey, gray, Tears now have a random chance to freeze enemies in place, The chance to freeze enemies is affected by your luck stat, Chance to activate increases with luck, up to around 50% chance at +20 luck, UNLOCK: Unlock this item by collecting 3 'Mom' items in one playthrough, * item room, treasure room, item room pool, dungeon room, blood challenge room, arena pool, REPENTANCE - Bob's Curse bombs now leave behind a gas cloud that poisons enemies that move through it. Items If an enemy is killed while it is golden, it will drop between 1-4 coins, Contact damage is also dealt to enemies equal to the amount of coins Isaac is currently holding, Has a synergy with The Poop item, which gives it a high chance to spawn golden poops, * item room, treasure room, item room pool, gold, ingot, bar, orange, All future pennies, keys, bombs and hearts have a chance to drop in pairs, Does not work for other pickups, such as soul hearts, nickels, dimes, cards, pills etc, REPENTANCE - No longer guarantees all pickups to be doubled (is now chance-based), and doesn't change existing pickups that already dropped, * Humbling bundle shop room pool, shop item pool, paper, purple, brown, When you take damage, there is a 50% chance to drop a random heart, key, bomb or coin, * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, shop room pool, shop item pool, bag, satchel, backpack, purse, satchel, brown, When your spacebar item is not fully charged, you can press spacebar to recharge it at the cost half of a heart per charge, Will not kill you if used - it stops a half a heart left, Red hearts are taken before other kinds, i.e. The door can only be opened if you have The Polaroid, The Negative or Faded Polaroid (the item/trinket is taken away when it opens). Seeds Attributes Clot Clots crawl in random directions, shooting 4 tears horizontally . Doing so will cause it to increase in size, and also increase their damage and the damage of the burst tears, Once a tear is fed 5 times, it will immediately burst, Tears in the burst will deal half the damage the main tear would have, Added as part of the Afterbirth+ Booster Pack #4. Completion Marks pedestal items, Picking up all dropped items leaves you with the same health and consumables you had before, This allows you to manipulate your consumables in lots of different ways, for example by rerolling them with the D6/D20, re-arrange your Bone heart containers and more, If you have the Tarot Cloth item, this card will also drop all your passive items on the floor as pedestals, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Lost, Gives you a blue aura that repels enemy projectiles, causing them to slowly curve away from Isaac and avoid hitting him, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Judas, Causes Mom's Foot to keep stomping down randomly for 60 seconds where Isaac is standing, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Lilith, Gives 2 HP Up and +1.5 Tears Up for 60 seconds, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Eve, Teleports you to an extra boss room, that drops a Boss room item as normal. The creep deals 2 damage per tick while enemies stand in it, Lazarus' revived form (Lazarus II) respawns with this item, * item room, treasure room, item room pool, blood drop, red blood, drip, Gives Isaac a guaranteed devil or angel room on every floor that they can appear, even if you have already beaten the boss and it didn't show up originally, Taking the Goat Head (or any other item) in a Devil Deal bars you from encountering Angel Rooms naturally. Having a higher movement speed allows you to kick it harder, Enemies hit by the cube while moving have a high chance to become frozen. Rotten Meat = +1 flat damage, +1.5 range. *, brown, red, tup, carton, box, golden chest pool, gold chest pool, Item Pool: Boss Room, Gold/Stone Chest, Mom's Chest, *, white, necklace, grey, gray, moms pearls, mom pearls, The Car Battery causes your spacebar item to activate twice on each use, For example, with Yum Heart you would heal 2 full red hearts instead of 1, Upon use, gives you a duplicate of each familiar you have for the current room, It will not 'double' your familiars as the tagline suggests - if you have 2 of one kind, it will only give you an extra one, If the familiar only appears when taking damage (i.e. Upon hitting the floor, an obstacle, or an enemy they burst into smaller tears in all directions. On my previous version of this guide, I made the mistake of assuming nobody would need a version that just had everything, since various wikis already have that. If the heart is hit, Isaac will take damage, Most enemies will target the heart over Isaac himself, Blood donation machines and devil beggars can be used for free. After dealing enough damage it will eventually disappear, At full size the flame deals 6x your tear damage, scaling down to 3x at its smallest size, The chance to for each tear to become a flame is affected by your luck stat and at +10 Luck it will activate 50% of the time (starts at 8.33% at +0 Luck), Each tear now has a small chance (3.33%) to be a needle instead, which deals 3 times your tear damage, If a needle hits a non-boss enemy it will instantly kill it and will explode into a circle of 10 more needles, The 10 spawned needles will also deal 3 times your tear damage, but won't instantly kill enemies or explode into more needles, The chance to for each tear to become a needle is affected by your luck stat and at +15 Luck it will activate 50% of the time, UNLOCK: Unlock this item by defeating Delirium in The Void floor with Lilith, *, black, syringe, injection, euthansia, dang, dan gheesling, dangheesling, dangDEB8, you piece, Upon entering a new room, Isaac will become camouflaged and enemies won't attack until you start firing tears, Camo Undies grants +0.5 speed while cloaked, When uncloaking, all nearby enemies take damage, and Isaac gains a brief tears + damage up, *, pink, purple, goggles underwear under wear, Any time a devil or angel room door opens after a boss, the other one will also spawn, The extra door will only spawn if a devil or angel room was randomly chosen to spawn already, After entering one of the doors, the other will disappear, If there isn't an available wall for the extra door to spawn on, only one door will spawn (i.e. *, bag, grey, cry, blue, tear, shia paper bag sackhead, sad, Gives Isaac a cone of light infront of him that slows any enemies inside it and their tears, The light faces the direction that you are facing, not the direction you are firing, Removes Curse of Darkness for the current floor, if picked up on a floor where the curse is active, * Shop, Greed Mode Item Room, white, blue, inhaler, A purple familiar fly that follows your exact movement on a 1 second delay and deals 2 contact damage to enemies, When used, places an explosive TNT barrel next to you, The TNT barrel can be pushed and used to explode rocks or damage enemies, If used a second time in the same room while the last TNT barrel is still there, it will remotely explode the first TNT and not spawn another, REPENTANCE - Added to the Gold Chest Pool. spikes, creep). Glass Cannon allows you to fire one huge spectral tear that deals a lot of damage. with Brimstone you get 4 lasers, Counts as 1 of 3 spider items needed towards the Spider Baby transformation, * item room, treasure room, item room pool, green, black, +2 Damage Up for tears fired from Isaac's left eye, If playing as Cain or you have an item which modifies which eye you fire tears from, each shot has a 50% chance to do +2 Damage, * item room, treasure room, item room pool, poison, green, brown, bottle, jar, danger, Gives Isaac an eye companion that floats around the room and deals 8 damage per tick on contact with enemies, Damage from Isaac's left eye deal roughly +35% damage, * item room, treasure room, item room pool, red, white, When you take damage, this item recharges one room's worth of charge to your spacebar item, For example, with the D6 you would need to take damage 6 times to fully recharge it, * angel room pool, god room pool, angel room item, shop room pool, shop item pool, One of the sounds lasers can make when Isaac's tear size is large (or when damage is 10.0 or more). UNLOCK: Unlock this card by opening Mom's Box on the Home floor. Brimstone: Brimstone has priority. The medical name for a blood clot is a 'venous thromboembolism'. Tears are fired in an arc. Completion Marks Also got libra but just a basic all stats up. *, stone, rock, grey, gray, white, dice, pip, broken, die, While held this trinket causes all pickups and enemies to move slowly towards you, Will also attract the Mom's Foot and Ultra Greed door entities, *, white, grey, gray, pill, medicine, drug, Randomly Isaac will gain a camouflage for a few seconds and all enemies in the current room will have a confused status effect applied to them, This trinket can be used to open the door to Mausoleum in Depths II, Gives a small chance to spawn a friendly attack spider while in a hostile room with enemies, Leaves a pool of green creep under all bombs you place, which damages enemies that walk over it, *, green, bogey, snot, ocarina, bobs bladder, bob bladder, Gives a +6.66% chance of a getting a small battery after clearing a room, Gives a +2.0% chance for pickups to be small batteries, Gives a +5.0% chance to add an extra charge to your active item after clearing a room, *, metal, grey, gray, silver, pill, cross, Exploding bombs now have a chance to drop another bomb that you can pick up, Higher chance to find crawl spaces when exploding rocks, UNLOCK: Unlock this trinket by beating Challenge #27 (Brains), *, toe, finger, thumb, grey, gray, black, red, yellow, Gives a different trinket effect per room, randomly choosing between any of the other available trinkets in the game. poop, pots, TNT, red poop, stone blocks, spikes, fireplaces etc. Afterbirth didn't exist and probably wasn't even planned. (6 full hearts to fully charge), Unless fully charged, hearts picked up are consumed by the Alabaster Box, instead of being added to your life total. Blood Clot / Chemical Peel / The Peeper: 50% chance to apply the flat damage up/damage increase with each shot. After a few seconds a huge missile hits the target and deals 20x your tear damage to anything nearby, Essentially a one-time use of the Epic Fetus item, * item room, treasure room, item room pool, grey, gray, robot, Isaac's tears now have a piercing effect which allows them to travel through enemies instead of breaking on hit, * item room, treasure room, item room pool, arrow, penetrative, penetrating shots, grey, gray, Update 1.7.7 has arrived for The Binding of Isaac: Rebirth, and here's the full list of changes and fixes added with this patch. Tears have a 50% chance to be Blood Clot tears. Placing a bomb while pressing a fire button will fire an explosive rocket in that direction, Placing a bomb while standing still will place a regular bomb, Upon use, spawns a flame familiar that fires spectral tears and deals contact damage to enemies. slow, shrink, fear), Spider Mod will also randomly drop battery consumables or blue spiders when a room is completed, For the sake of simplicity for players, all damage values displayed are multiplied by 10 and rounded to the nearest number, This item is a reference to Spider853, creator of Spidermod for the original game and one of the lead developers that worked on Rebirth and its DLCs, *, robot, red, grey, gray, silver, metal, antenna, A familiar that follows Isaac and blocks tears, If a tear hits Farting Baby, there is a 10% chance for it to fart, with 3 possible effects: Charm, Poison or Knock back, Charm deals 5 damage. Fort Myers, FL - Isaac James Blood, 46, of Brewer, Maine, and Fort Myers, Florida, passed away unexpectedly in his sleep on December 26, 2022. Manage all your favorite fandoms in one place! leaving a trail of blood that damages the player. Lil Clot is an unlockable trinket added in The Binding of Isaac: Repentance. Finding all the puzzle pieces will help you to reveal the final secret, unlocking the hidden character 'The Lost', If held when you touch the chest after the Satan or Isaac fight and you don't have the relevant item to go to the next floor (Polaroid or Negative), you have a small chance to be taken there anyway, UNLOCK: Unlock this item by beating the Chest with Eden, 80% of heart drops are replaced with keys, Hearts turn into black hearts where possible. Every 6 coins Bumbo will evolve to a new form except for level 4 which takes 12 coins, Level 2: Bumbo gains a body and crawls around the room, sometimes dropping random pickups, Level 3: It now fires tears in the same direction Isaac does, Level 4: Bumbo no longer fires tears but instead will chase enemies slowly and deal contact damage. Modes * , the lost item pool, head, bone, grey, gray, Gives Isaac a higher chance to find pills, Gives Isaac a higher chance to find Tarot cards after clearing a room or from chests, After clearing a room, you have a chance to heal for half a red heart, *, the lost item pool, silver, metal, grey, gray, isaacs fork, When taking damage, Isaac has a chance to deal damage to the entire room in a Necronomicon style effect, The chance to damage enemies is affected by your luck stat and at +50 or more Luck it will activate 50% of the time, * , the lost item pool, pink, purple, paper, red, Everytime you pick up a penny, you have a 25% chance to spawn a red heart on the floor, UNLOCK: Unlock this item by beating the Chest with Samson, * , the lost item pool, red, coin, cent, money, Everytime you pick up a coin, you have a 25% chance to spawn a bomb on the floor, UNLOCK: Unlock this item by beating Challenge #13 (Beans! It is possible to charge before entering a room so that the first shot can be fired immediately. Tears continue to fire from your left eye, The laser deals damage equal to 1/7th of your tear damage, but very rapidly, The laser can apply status effects (e.g. Pressing it again allows you to throw it at enemies. It can spawn familiars you haven't unlocked yet! UNLOCK: Unlock this trinket by collecting three of the following in the same run: Magic 8 Ball, Tiny Planet, Crystal Ball, Star of Bethlehem or any of the Astrology-related items (e.g. For example, an item which usually gives +1 Damage would instead give a small 'all stats up', Stats effected by this item are: Damage, Tears, Range, Speed, When taken with another item which gives an extreme value in a certain stat (e.g. - Turns Isaac invincible for a few seconds (similar to Unicorn Stump). Chapters Item Pool Brimstone's item icon originally comes from the alchemical symbol for. blue, glow, 69, Isaac increases in size, gets a lion's mane and now has the ability to crush rocks by walking over them, Crushed rocks and poop can fill holes if you walk in their direction, Allows you to crush Red Poops and sometimes not take damage. Characters Shows you to see the contents of chests, sacks, shopkeepers and items that will drop from fires before you destroy them, Doesn't work on tinted rocks and other obstacles (e.g. Manage all your favorite fandoms in one place! Stat Up becomes Stat Down), Any 'Stat down' pills you take give you a permanent +0.6 Damage Up (Horse pills +1.2), Most other pills spawn a black heart when used, including R U A Wizard?, Amnesia, Bad Trip, ?? Taking this item DOES count as a devil deal, preventing future angel rooms. Charge time increased to 4 (from 2), UNLOCK: Unlock this item by dying 100 times, * item room, treasure room, item room pool, grey, gray, Holding the active item button will deplete the charge bar. Based on the Steam Workshop mod created by Niro, A familiar with a charged attack, that spawns a line of creep on the floor which damages enemies that walk over it, The familiar and its creep will change randomly when Isaac uses a pill, Possible creep types include green (deals damage), black (slows enemies), red (deals damage, forms a line with a larger puddle), yellow (deals damage, forms a short-range cone) and white (slows enemies, forms a ring), Added as part of the Afterbirth+ Booster Pack #5. Entity ID For the current room, tears now have the Spoon Bender effect, which allows them to curve towards enemies and gives them a purle appearance. ), Prevents your stats from being reduced any more for the rest of the run, e.g. Unlocked from the 'Once more with the feeling!' 25 Of The Best Items In The Binding Of Isaac. UNLOCK: Unlock this card by beating Challenge #9 (Demo Man), Temporarily makes Isaac huge, giving him +7 Damage Up and +30 Range Up for the rest of the current room, Added as part of the Afterbirth+ Booster Pack #1 and based on the Steam Workshop mod created by Coper140, UNLOCK: Unlock this item by getting 5 items or consumables that increase your size, e.g. Blood Clot doesn't work with Lilith since she . This effect stacks with multiple shades, scaling the contact damage each time, UNLOCK: Unlock this item by defeating Delirium in The Void floor with Judas, Isaac gains a cloud familiar that follows him and leaves a trail of tears on the floor which damages enemies for 2 damage per tick, Enemies touching the cloud have a chance to activate the Crack the Sky effect, which spawns a light beam that deals damage equal to your tear damage + 20, Gives Isaac a small Hush familiar that bounces diagonally around the room dealing 2 contact damage per tick, While you're firing tears Hushy will stop moving, which allows you to keep it in one place, Hushy will block enemy tears and projectiles, UNLOCK: Unlock this item by beating Hush with Apollyon, Gives Isaac a small Monstro familar, who's tears can be charged and released in a shotgun style effect, much like Monstro's main attack, Lil Monstro's tears each deal base damage (3.5) and don't scale with damage upgrades, *, head, cleft, lip, palate, hairlip, tooth, A baby familiar that follows you and causes other familiars to follow it. Picking up Brimstone will multiply Isaac's current damage by 3. ?, Paralysis, Retro Vision, I'm Excited, While held, gives you an orbital that blocks enemy shots and deals contact damage equal to 3.5 per tick, While the active key is held down, Isaac gains +0.5 Speed and all of your orbitals spin faster and deal more damage, Orbital damage is equal to 1.5 x OrbitalDamage + 6 while this effect is active, On death enemies now fire tears in random directions, which can damage other enemies, The amount of tears created by this effect depends on the total health of the enemy killed. Each time you clear a room there is a chance a Red Room will spawn at one of the walls. When you take damage and the cannon breaks, you take an additional 2 full hearts of damage and gain the Anemic effect for the room. Collection Grid Even if Isaac have not finished charging Brimstone when he'll pass through a door, it is always fully charged once a new room is entered if the fire button is still being held. Unlocked from the 'U broke it!' Following the path takes you to an abandoned mineshaft, which leads you to a pedestal with the Knife Piece. This is to prevent a syngery like Dr. Fetus or a Golden Bomb giving you infinite resources, Isaac's shadow will follow closely behind him and when it comes into contact with enemies, will spawn friendly dark charger mobs, The chargers deal contact damage to enemies, and will be killed if it is hurt too much, Chargers disappear upon entering a new room, UNLOCK: Unlock this item by beating Greed Mode with Judas, Every time you kill an enemy a fly will be added to the Jar, allowing you to stack up to 20, Using the Jar of Flies will release all the flies that are currently in the jar as friendly flies that will damage enemies, A Loki familiar that follows Isaac and shoots tears 4 tears in a cross pattern, dealing a flat 3.5 damage each, Gives Isaac a familiar glass of milk that follows him and spills on the floor upon taking damage, After being spilt, the milk gives you a -2 Tear Delay (Tears up) for the rest of the room, When used, the D7 will restart the current room and bring back all enemies once again, enabling you to farm rewards that spawn at the end after beating the room, Can be used to generate infinite consumable combinations, gaining as many coins/keys/bombs as you need, This item has no effect in Greed Mode, Challenge Rooms and rooms that had no enemies in originally, If used in a Boss Room or Angel/Devil Room, you get teleported to another random room, which is reset instead of the boss/angel/devil room you were in, Enemies respawned by the D7 don't drop loot if they were champions and also don't grant score in daily runs, * dice, pip, die, turban, white, grey, gray, Makes Isaac very small like a baby, reducing his hitbox size, When used, Mom's Box will drop a random trinket on the ground, While held, doubles the effect of trinkets which make sense to be doubled (e.g. Invincible for a few seconds ( similar to Unicorn Stump ) feeling! up/damage increase with each shot invincible a... 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